Ensayos clínicos de tumores cerebrales

Título completo:

ACNS2021: A Phase 2 Trial of Chemotherapy Followed by Responsebased Whole Ventricular and Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor

Meta de estudio:

To study chemotherapy plus response-based radiation for non-germinomatous germ cell tumor

Diagnóstico:

Non-germinomatous germ cell tumor

Edad:

3–29 years

Título completo:

A Phase II Trial Evaluating Chemotherapy Followed by Response-Based Reduced Radiation Therapy for Patients with Central Nervous System Germinomas

Meta de estudio:

To study carboplatin, etoposide, and lower-dose radiation therapy for germinoma.

Diagnóstico:

Germinoma

Edad:

3–29 years old

Título completo:

Project:EveryChild: A Registry, Eligibility Screening, Biology and Outcome Study.

Meta de estudio:

To gather data from childhood cancer patients and their families that will help to improve diagnosis, treatment, and survival.

Diagnóstico:

Childhood cancer

Edad:

Up to age 25

Título completo:

CHRONCAN (Chronicling Cancer): Piloting a Novel Writing Intervention with Adolescents and Young Adults with Cancer

Meta de estudio:

To assess the feasibility and acceptability of a writing-based narrative medicine intervention for adolescent and young adult patients with cancer.

Diagnóstico:

Childhood cancer

Edad:

15–25 years

Título completo:

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Meta de estudio:

To better understand the prevalence of sleep disorders in long-term survivors of childhood ALL, CNS tumors, and non- CNS solid tumors

Diagnóstico:

Acute lymphoblastic leukemia, brain and spine tumors, solid tumors, retinoblastoma

Edad:

18 years and older

Título completo:

Phase 2 Study of Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age with NTRK1/2/3 or ROS1-fused CNS Tumors (GLOBOTRK)

Meta de estudio:

To find out whether entrectinib is effective in treating brain tumors with NTRK or ROS1 fusions

Diagnóstico:

High-grade glioma and other CNS tumors

Edad:

Birth–3 years old

Título completo:

Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

Meta de estudio:

The main purpose of this study is to find out what happens, good and bad, to memory and learning when the hippocampus is avoided during proton therapy radiation.

Diagnóstico:

Low-grade glioma

Edad:

At least 6 years old and younger than 22

Título completo:

A Randomized, Placebo-Controlled, Double-Blind Phase 2 Study to Assess Efficacy and Safety of LB54640 in Patients with Hypothalamic Obesity, with an Open-Label Extension 

Meta de estudio:

To find out if taking the medicine LB54640 is safe and effective to control the weight and hunger of people with hypothalamic obesity.

Diagnóstico:

Brain tumors

Edad:

12 and up

Título completo:

Locoregional Delivery of B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cells for Pediatric Patients with Primary CNS Tumors

Meta de estudio:

The purpose of this study is to find: 1) the largest dose of Loc3CAR T cells that is safe to give patients with B7-H3–positive brain tumors; 2) the side effects of Loc3CAR T cells; 3) the effect Loc3CAR T cells have on brain tumors. This trial will help scientists better understand how the immune system fights this kind of tumor. What we learn from this study could help us create better treatments.

Diagnóstico:

Brain tumors, DIPG, DMG

Edad:

Up to 21 years old

Título completo:

PACTPAT: Preclinical Assessment of Cell Therapies – Patient Samples

Meta de estudio:

To study how immune cells from children and young adults with cancer can be used to create safer, more effective cell therapies.

Diagnóstico:

Childhood cancer, Brain tumors, Leukemia, Lymphoma, Solid tumors

Edad:

Infants to adults

Título completo:

Optune for Children with High-Grade Glioma or Ependymoma, and Optune with Radiation Therapy for Children with DIPG

Meta de estudio:

To see how well children with high-grade glioma and ependymoma can use the Optune device and what side effects it may cause; and to see if Optune and radiation therapy are safe and effective for diffuse intrinsic pontine glioma. 

Diagnóstico:

High-grade glioma (HGG), ependymoma, DIPG

Edad:

3-21 years

Título completo:

PEPN2415: A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD1390 When Combined with Focal Radiation in Pediatric Patients with High-Grade Glioma

Meta de estudio:

To study AZD1390 combined with radiation therapy for treating pediatric high-grade glioma.

Diagnóstico:

High-grade glioma, diffuse midline glioma, and diffuse intrinsic pontine glioma

Edad:

1–22 years old

Título completo:

RIGHTimeCPV: Revealing Information Genuinely and Honestly across Time – Communication Preferences Visit

Meta de estudio:

To study clear and honest communication to improve and support prognostic communication for cancer among physicians, patients, and families

Diagnóstico:

Childhood cancer, Brain tumors, Solid tumors, Leukemia and lymphoma

Edad:

Patient: age 12-25
Parent or caregiver: age 18 and older

Título completo:

SJ901: Phase 1/2 Evaluation of Single Agent Mirdametinib (PD-0325901), a Brain-Penetrant MEK1/2 Inhibitor, for the Treatment of Children, Adolescents, and Young Adults With Low-Grade Glioma

Meta de estudio:

The main goal of this study is to test the experimental drug mirdametinib in hopes of finding a treatment that may be effective against low-grade glioma brain tumors in children, adolescents and young adults.

Diagnóstico:

Low-grade glioma

Edad:

At least 2 years old and younger than 25 years old.

Título completo:

SJLIFE: Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer

Meta de estudio:

To establish a lifetime group of childhood cancer survivors treated at St. Jude Children’s Research Hospital and to evaluate health outcomes in aging survivors of pediatric cancer

Edad:

Participants must be at least 5 years from diagnosis of childhood cancer between 1962-2012, treated and followed at St. Jude

Título completo:

SJLTFU: Protocol for Collecting Data on Childhood Cancer Survivors

Meta de estudio:

To collect information about the effects of childhood cancer and its treatment on the patients who are treated or followed after treatment for childhood cancer at St. Jude Children’s Research Hospital

Título completo:

SJiMB21: Phase 2 Study of Molecular and Clinical Risk-Directed Therapy for Infants and Young Children with Newly Diagnosed Medulloblastoma

Meta de estudio:

This study uses a risk-directed approach to find out which types of treatment will work best and have the fewest side effects for infants and children with medulloblastoma.

Diagnóstico:

Medulloblastoma

Edad:

Birth to 5 years old

Título completo:

Components of Social Functioning in Survivors of Pediatric Brain Tumors

Meta de estudio:

Examine the impact of social-cognitive and neurocognitive abilities on social functioning in survivors of pediatric brain tumors

Diagnóstico:

Brain tumor

Título completo:

TOPNOTCH: Navigating Oncology Patients to Successful Transitions of Care and Health

Meta de estudio:

To learn how to define a “successful transition” after cancer treatment, identify barriers and supports, and develop an assessment tool to guide care.

Diagnóstico:

Childhood cancer, Brain tumors, Leukemia, Lymphoma, Solid tumors

Edad:

12 and older

Título completo:

Understanding Communication in Health Care to Achieve Trust: A Prospective Longitudinal Investigation of Communication between Pediatric Oncologists, Children/Adolescents with High-Risk Cancer, and their Families at the Stressful Times of Disease Relapse or Progression

Meta de estudio:

To identify recurrent verbal and nonverbal communication techniques employed by pediatric oncologists in the delivery of difficult prognostic information to parents through content analysis of audio recorded conversations between pediatric oncologists and parents of children with high-risk cancer at times of disease re-evaluation

Diagnóstico:

Non-therapeutic

Edad:

Patients: Age 30 or younger
Parents: Age 18 or older