Ensayos clínicos de tumores sólidos

Título completo:

3CAR: B7-H3-specific Chimeric Antigen Receptor Autologous T-cell Therapy for Pediatric Patients with Solid Tumors

Meta de estudio:

The main purpose of 3CAR is to find out if this type of immunotherapy is safe for pediatric patients with solid tumors. We also want to learn if it is effective in fighting solid tumors.

Diagnóstico:

Solid Tumor

Edad:

Up to 21 years old

Título completo:

AGCT1531: A Phase 3 Study of Active Surveillance for Low-risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard-risk Pediatric and Adult Patients with Germ Cell Tumors

Meta de estudio:

Watch patients with low-risk germ cell tumors, after tumor removal, treats their tumor as well as if they got the usual treatment of chemotherapy and/or more surgery if needed.

Diagnóstico:

Germ cell tumor, Yolk sac tumor

Edad:

Standard Risk Group 1: less than 11 years old; Standard risk Group 2: ages 11–25

Título completo:

AGCT1532: A Randomized Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumors

Meta de estudio:

The purpose of this study is to find out if accelerated chemotherapy will treat germ cell tumors as well as standard. We will also see if both treatments have similar side effects and are well tolerated.

Diagnóstico:

Germ cell tumor

Edad:

Ages 11–45 years

Título completo:

ANBL2131, A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children with Newly Diagnosed High-risk Neuroblastoma

Meta de estudio:

To find out whether adding dinutuximab with chemotherapy, early in treatment, treats high-risk neuroblastoma better than adding it later with chemotherapy.

Diagnóstico:

Neuroblastoma or ganglioneuroblastoma

Edad:

Up to 30 years old

Título completo:

Safety and Tolerability of Oral Cyclophosphamide and Sorafenib with Intravenous Bevacizumab with the Addition of Atezolizumab in Pediatric Solid Tumor Patients

Meta de estudio:

In Part 1 of this study, we will see if sorafenib, cyclophosphamide, bevacizumab, and atezolizumab can be given safely together without causing serious side effects. Part 2 of the study will find out how well these medicines work in hepatocellular carcinoma, fibrolamellar carcinoma, desmoplastic small round cell tumors, and malignant rhabdoid tumors.

Diagnóstico:

Solid tumors, hepatocellular carcinoma, fibrolamellar hepatocellular carcinoma, sarcomas, malignant rhabdoid tumors, desmoplastic small round cell tumors

Edad:

1-30 years old

Título completo:

A Feasibility and Randomized Phase 2/3 Study of the VEGFR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma

Meta de estudio:

Find the highest dose of cabozantinib that can be given safely along with MAP chemotherapy; compare the effects of cabozantinib along with MAP and surgery versus MAP and surgery alone to find out which is better.

Diagnóstico:

Osteosarcoma

Edad:

Less than 40 years old

Título completo:

Project:EveryChild: A Registry, Eligibility Screening, Biology and Outcome Study.

Meta de estudio:

To gather data from childhood cancer patients and their families that will help to improve diagnosis, treatment, and survival.

Diagnóstico:

Childhood cancer

Edad:

Up to age 25

Título completo:

A Phase 2 Study Using Chemoimmunotherapy with Gemcitabine, Cisplatin, and Nivolumab in Newly Diagnosed Nasopharyngeal Carcinoma (NPC)

Meta de estudio:

To find out what effects adding nivolumab to chemotherapy has on people with newly diagnosed NPC.

Diagnóstico:

Nasopharyngeal carcinoma

Edad:

21 years old or younger

Título completo:

A Prospective Phase 3 Study of Patients with Newly Diagnosed Very Low-Risk and Low-Risk Fusion Negative Rhabdomyosarcoma

Meta de estudio:

Compare the effects of giving less chemotherapy drugs to people with VLR-RMS, who do not have the MYOD1 or TP53 mutation, to find out which is better; to find out how well people with LR-RMS, without MYOD1 or TP53 mutations, respond to standard chemotherapy, and to see the effects of giving chemotherapy drugs for a longer amount of time. We want to see if patients with RMS and the MYOD1 or TP53 mutation benefit from longer therapy than the shorter treatment we give to VLR or LR patients.

Diagnóstico:

Rhabdomyosarcoma

Edad:

Up to 21 years old

Título completo:

A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects with Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1–3 Alterations

Meta de estudio:

To find out whether repotrectinib is safe to use in children and young adults and whether it might work against tumors.

Diagnóstico:

Neuroblastoma, Wilms tumor, rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, retinoblastoma, hepatoblastoma, medulloblastoma, germ cell tumors

Edad:

Up to 25 years old

Título completo:

CHRONCAN (Chronicling Cancer): Piloting a Novel Writing Intervention with Adolescents and Young Adults with Cancer

Meta de estudio:

To assess the feasibility and acceptability of a writing-based narrative medicine intervention for adolescent and young adult patients with cancer.

Diagnóstico:

Childhood cancer

Edad:

15–25 years

Título completo:

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Meta de estudio:

To better understand the prevalence of sleep disorders in long-term survivors of childhood ALL, CNS tumors, and non- CNS solid tumors

Diagnóstico:

Acute lymphoblastic leukemia, brain and spine tumors, solid tumors, retinoblastoma

Edad:

18 years and older

Título completo:

18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

Meta de estudio:

The main goal of this study is to test the safety of 18F-DA in children with neuroblastoma or pheochromocytoma.

Diagnóstico:

Neuroblastoma, pheochromocytoma

Edad:

At least 1 year old

Meta de estudio:

The main goal of this study is to learn more about the reasons childhood tumors form and how to treat them better.

Diagnóstico:

Leukemia, lymphoma, genetics and genomics, solid tumor

Título completo:

HuNB803 (NANT 2023-01): A Safety Run-In and Phase 2 Randomized Trial of Chemoimmunotherapy Administered with or Without N-803, a Novel IL-15 Superagonist, for the Treatment of Patients with Relapsed or Refractory Neuroblastoma

Meta de estudio:

To study the safety of combining N-803 with chemotherapy and immunotherapy for relapsed and refractory neuroblastoma. To study whether N-803 plus chemotherapy and immunotherapy works better than chemotherapy plus immunotherapy alone.

Diagnóstico:

Neuroblastoma

Edad:

Up to 30 years

Título completo:

International Pediatric Adrenocortical Tumor Registry

Meta de estudio:

The main goal of IPACTR is to collect relevant clinical and biological data, including blood and tissue samples, to help researchers better understand the 1) common signs and symptoms of ACT, 2) length of time between the first signs and symptoms and diagnosis of ACT, 3) how genetic conditions such as Li-Fraumeni and Beckwith-Wiedemann syndrome make a person more likely to develop ACT, 4) family history of cancer in relatives of children with ACT, 5) how children with ACT in different parts of the world are treated, and 6) how the genetic makeup affects survival in children and relatives with ACT.

Diagnóstico:

Adrenocortical tumors (carcinoma and adenoma)

Edad:

21 years of age or younger at diagnosis

Título completo:

A Phase 1/2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Recommended Phase 2 Dose (RP2D), and Efficacy of Lurbinectedin Monotherapy in Pediatric Participants with Previously Treated Solid Tumors Followed by Expansion to Assess Efficacy and Safety in Pediatric and Young Adult Participants with Relapsed/Refractory Ewing Sarcoma

Meta de estudio:

To find out whether Lurbinectedin is safe in treating children and young adults who have refractory or relapsed Ewing sarcoma

Diagnóstico:

Ewing sarcoma

Edad:

2–30 years old

Título completo:

Larotrectinib to Enhance RAI Avidity in Patients with Differentiated Thyroid Cancer Harboring NTRK fusions

Meta de estudio:

To study larotrectinib in patients with NTRK fusions and differentiated thyroid cancer that has spread to the lungs

Diagnóstico:

Differentiated thyroid cancer

Edad:

1 year and older

Título completo:

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Meta de estudio:

Researchers in this study want to learn more about melanoma tumors in children and adolescents. They want to understand the different types of tumors better and learn how each type responds to treatment. They also want to find out why some children and teens are more likely to develop melanoma. Doctors hope this information will help them decide which melanoma treatments are most effective. They also hope to use this information to develop new treatments for children with melanoma.

Diagnóstico:

Melanoma

Edad:

Up to 18 years old

Título completo:

PACTPAT: Preclinical Assessment of Cell Therapies – Patient Samples

Meta de estudio:

To study how immune cells from children and young adults with cancer can be used to create safer, more effective cell therapies.

Diagnóstico:

Childhood cancer, Brain tumors, Leukemia, Lymphoma, Solid tumors

Edad:

Infants to adults

Título completo:

Mobile Technology to Improve Pain and Symptoms in Children With Cancer

Meta de estudio:

The main goal of this research study is to help us learn how to better treat pain and symptoms in children going through chemotherapy cancer treatment.

Diagnóstico:

ALL, AML, carcinoma, endocrine tumors, lymphoma, melanoma, neuroblastoma, retinoblastoma, Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, sarcomas

Edad:

8 to 18 years old

Título completo:

A Phase 1/2 Study of Tegavivint (IND#156033, NSC#826393) in Children, Adolescents, and Young Adults with Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Meta de estudio:

The main purpose of this study is to find out how well the medicine tegavivint works to help children, teens, and young adults with certain recurrent or refractory solid tumors.

Diagnóstico:

Solid tumors, Non-Hodgkin lymphoma, Desmoid tumors, Ewing sarcoma, Osteosarcoma, Hepatocellular carcinoma, Hepatoblastoma, Wilms tumor

Edad:

12 months to 30 years

Título completo:

A Phase 1/2 Trial of CBL0137 in Patients with Relapsed or Refractory Solid Tumors including CNS Tumors and Lymphoma

Meta de estudio:

The main purpose of this study is to find the highest, safest dose of CBL0137 that can be given to children, teens and young adults with solid tumors or lymphoma.

Diagnóstico:

Solid Tumor, Lymphoma, Brain Tumor, DMG

Edad:

12 months to 21 years old with diagnosis of relapsed or refractory solid tumor or lymphoma (including CNS tumors) or progressive or recurrent DIPG or other H3 K27M-mutant diffuse midline gliomas previously treated with radiation therapy; 12 months to 30 years old with diagnosis of relapsed or refractory osteosarcoma

Título completo:

PROSPER: Prospective Evaluation of Delayed Effects of Pediatric CAR T Cell Therapy

Meta de estudio:

To study intermediate and long-term side effects of CAR-T cell therapy

Diagnóstico:

Leukemia, lymphoma, solid tumors

Título completo:

RIGHTimeCPV: Revealing Information Genuinely and Honestly across Time – Communication Preferences Visit

Meta de estudio:

To study clear and honest communication to improve and support prognostic communication for cancer among physicians, patients, and families

Diagnóstico:

Childhood cancer, Brain tumors, Solid tumors, Leukemia and lymphoma

Edad:

Patient: age 12-25
Parent or caregiver: age 18 and older

Título completo:

A Protocol for the Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children with Intermediate- and High-risk Disease

Meta de estudio:

To find the most effective treatment for each risk group of rhabdomyosarcoma patients

Diagnóstico:

Rhabdomyosarcoma

Edad:

Up to 21 years old

Título completo:

SJLIFE: Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer

Meta de estudio:

To establish a lifetime group of childhood cancer survivors treated at St. Jude Children’s Research Hospital and to evaluate health outcomes in aging survivors of pediatric cancer

Edad:

Participants must be at least 5 years from diagnosis of childhood cancer between 1962-2012, treated and followed at St. Jude

Título completo:

SJLTFU: Protocol for Collecting Data on Childhood Cancer Survivors

Meta de estudio:

To collect information about the effects of childhood cancer and its treatment on the patients who are treated or followed after treatment for childhood cancer at St. Jude Children’s Research Hospital

Título completo:

Multi-Center Trial Sponsored by St. Jude Children's Research Hospital for the Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation

Meta de estudio:

The main goal of this study is to find out if proton therapy causes fewer long-term side effects in patients with Wilms tumor than standard radiation treatment.

Diagnóstico:

Wilms Tumor

Título completo:

TOPNOTCH: Navigating Oncology Patients to Successful Transitions of Care and Health

Meta de estudio:

To learn how to define a “successful transition” after cancer treatment, identify barriers and supports, and develop an assessment tool to guide care.

Diagnóstico:

Childhood cancer, Brain tumors, Leukemia, Lymphoma, Solid tumors

Edad:

12 and older

Título completo:

Thyroid Therapy to Increase RAI Uptake in Patients with Metastatic Differentiated Thyroid Cancer (TRAIT)

Meta de estudio:

To study radioactive iodine and targeted therapy for differentiated thyroid cancer

Diagnóstico:

Differentiated thyroid cancer

Edad:

Infants to adults

Título completo:

Understanding Communication in Health Care to Achieve Trust: A Prospective Longitudinal Investigation of Communication between Pediatric Oncologists, Children/Adolescents with High-Risk Cancer, and their Families at the Stressful Times of Disease Relapse or Progression

Meta de estudio:

To identify recurrent verbal and nonverbal communication techniques employed by pediatric oncologists in the delivery of difficult prognostic information to parents through content analysis of audio recorded conversations between pediatric oncologists and parents of children with high-risk cancer at times of disease re-evaluation

Diagnóstico:

Non-therapeutic

Edad:

Patients: Age 30 or younger
Parents: Age 18 or older

Título completo:

Feasibility and Safety of Indocyanine Green (ICG) Guided Sentinel Lymph Node Biopsy

Meta de estudio:

To study the ability of indocyanine green to identify important lymph nodes in the retroperitoneum during surgery for childhood solid tumors.

Diagnóstico:

Solid tumor, Wilms tumor, Rhabdomyosarcoma

Edad:

0-20 years old